Statements (62)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:Cyclin-dependent_kinase
|
| gptkbp:associated_with |
gptkb:Oncology
|
| gptkbp:discovered_by |
gptkb:Human
|
| gptkbp:function |
Promotes cell cycle progression
|
| gptkbp:genetic_studies |
Associated with various cancers
|
| gptkbp:has_homolog |
gptkb:Cyclin_D1
gptkb:Cyclin_D2 |
| gptkbp:has_role |
Cell cycle regulation
|
| https://www.w3.org/2000/01/rdf-schema#label |
Cyclin D3
|
| gptkbp:initiated_by |
p16 INK4a
p21 CIP1 p27 KIP1 |
| gptkbp:interacts_with |
gptkb:CDK6
CDK4 |
| gptkbp:involved_in |
G1 phase
G1/ S transition |
| gptkbp:is_essential_for |
Cell proliferation
|
| gptkbp:is_expressed_in |
gptkb:Lung
Pancreas Liver Various tissues Prostate Regulated by growth factors Breast tissue |
| gptkbp:is_involved_in |
Immune response
Apoptosis regulation Cellular metabolism Cellular proliferation Tumor microenvironment DNA damage response Cellular stress response Cellular communication Tumorigenesis Cellular response to stress Cellular signaling pathways Cellular signaling Stem cell maintenance Cellular homeostasis Metabolic regulation Cellular differentiation Cellular repair mechanisms Tissue regeneration Cellular aging Cellular apoptosis Cellular adhesion Cellular invasion Cellular migration Cellular response to stimuli Cellular growth control Cellular interaction Cellular response to environment |
| gptkbp:is_linked_to |
Cellular senescence
|
| gptkbp:is_part_of |
Cyclin-CDK complex
|
| gptkbp:is_regulated_by |
Transcription factors
|
| gptkbp:is_targeted_at |
Anticancer drugs
|
| gptkbp:located_in |
gptkb:Atom
|
| gptkbp:part_of |
Cell cycle
|
| gptkbp:promoter |
CCND3
|
| gptkbp:regulates |
Cell division
|
| gptkbp:type |
gptkb:protein
|
| gptkbp:bfsParent |
gptkb:CDK6
|
| gptkbp:bfsLayer |
7
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