|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:BRAF
|
|
gptkbp:biologicalProcess
|
protein kinase activity
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:discoveredBy
|
Marx et al.
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:encodedBy
|
gptkb:BRAF_gene
|
|
gptkbp:Entrez_Gene_ID
|
673
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.1
|
|
gptkbp:family
|
gptkb:RAF_kinase_family
|
|
gptkbp:function
|
serine/threonine-protein kinase
|
|
gptkbp:gene
|
gptkb:BRAF
|
|
gptkbp:HGNC_ID
|
1097
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
B-RAF1
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_signaling_pathway
|
|
gptkbp:locatedOnChromosome
|
gptkb:7q34
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
colorectal cancer
melanoma
V600E
|
|
gptkbp:OMIM
|
164757
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:1UWH
|
|
gptkbp:phosphorylates
|
gptkb:MAP2K1
gptkb:MAP2K2
|
|
gptkbp:RefSeq
|
NP_004324.2
|
|
gptkbp:regulates
|
cell differentiation
cell growth
|
|
gptkbp:target
|
gptkb:encorafenib
gptkb:dabrafenib
gptkb:vemurafenib
|
|
gptkbp:UniProtID
|
gptkb:P15056
|
|
gptkbp:bfsParent
|
gptkb:BRAF_gene
|
|
gptkbp:bfsLayer
|
5
|