|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:v-raf_murine_sarcoma_viral_oncogene_homolog_B1
gptkb:B-RAF
|
|
gptkbp:associatedWith
|
gptkb:RASopathies
|
|
gptkbp:discoveredBy
|
Davies et al.
|
|
gptkbp:discoveredIn
|
2002
|
|
gptkbp:encodes
|
gptkb:B-Raf_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000157764
673
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:function
|
serine/threonine-protein kinase activity
|
|
gptkbp:GO_term
|
GO:0000187 (activation of MAPK activity)
GO:0005524 (ATP binding)
GO:0004674 (protein serine/threonine kinase activity)
|
|
gptkbp:HGNC_ID
|
1097
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Braf
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_signaling_pathway
|
|
gptkbp:length
|
18 exons
766 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:7q34
gptkb:chromosome_7
|
|
gptkbp:memberOf
|
gptkb:RAF_kinase_family
|
|
gptkbp:molecularWeight
|
84 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:V600K
gptkb:cancer
gptkb:Cardiofaciocutaneous_syndrome
gptkb:Noonan_syndrome
colorectal cancer
melanoma
D594G
G469A
V600E
|
|
gptkbp:OMIM
|
164757
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Braf_(mouse)
gptkb:Braf_(rat)
|
|
gptkbp:phosphorylates
|
gptkb:MEK1
gptkb:MEK2
|
|
gptkbp:product
|
gptkb:B-Raf
|
|
gptkbp:regulates
|
cell differentiation
cell survival
cell growth
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:targetOfDrug
|
gptkb:encorafenib
gptkb:dabrafenib
gptkb:sorafenib
gptkb:vemurafenib
|
|
gptkbp:UniProtID
|
gptkb:P15056
|
|
gptkbp:bfsParent
|
gptkb:BRAF_gene
|
|
gptkbp:bfsLayer
|
5
|