Langerhans cell histiocytosis

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:disease gptkb:histiocytic_disorder gptkb:rare_disease
gptkbp:affects	adults children
gptkbp:affectsOrgan	gptkb:bone gptkb:skin gptkb:pituitary_gland lungs liver lymph nodes spleen
gptkbp:associatedWith	gptkb:BRAF_V600E_mutation MAP2K1 mutation
gptkbp:category	gptkb:autoimmune_disease gptkb:neoplastic_disease immune system disease
gptkbp:causedBy	proliferation of Langerhans cells
gptkbp:firstDescribed	gptkb:Paul_Langerhans 1868
gptkbp:hasCellTypeInvolved	gptkb:Langerhans_cell
gptkbp:hasDiagnosticMethod	gptkb:blood_test imaging biopsy
gptkbp:hasEpidemiology	more common in children under 15
gptkbp:hasOrphanetID	ORPHA:535
gptkbp:hasRelatedDisorder	gptkb:Erdheim-Chester_disease gptkb:Rosai-Dorfman_disease
gptkbp:ICD-10_code	C96.6
gptkbp:incidence	1 in 200,000 children per year
gptkbp:MeSH_ID	D006391
gptkbp:OMIM	604856
gptkbp:prognosis	variable
gptkbp:symptom	gptkb:diabetes_insipidus fever weight loss bone pain skin rash enlarged lymph nodes
gptkbp:synonym	gptkb:Histiocytosis_X gptkb:LCH
gptkbp:treatment	gptkb:radiation_therapy surgery chemotherapy steroids
gptkbp:bfsParent	gptkb:Langerhans_cells gptkb:Touton_giant_cell gptkb:BRAF_gene gptkb:LCH
gptkbp:bfsLayer	6
https://www.w3.org/2000/01/rdf-schema#label	Langerhans cell histiocytosis