|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:NS7
gptkb:RAFB1
gptkb:B-RAF
gptkb:RAF-B1
|
|
gptkbp:associatedWith
|
gptkb:cardiofaciocutaneous_syndrome
gptkb:papillary_thyroid_carcinoma
gptkb:cancer
gptkb:Noonan_syndrome
colorectal cancer
melanoma
|
|
gptkbp:biologicalProcess
|
ATP binding
protein serine/threonine kinase activity
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:chromosomeArm
|
gptkb:7q34
|
|
gptkbp:discoveredBy
|
Davies H et al.
|
|
gptkbp:discoveredIn
|
2002
|
|
gptkbp:encodes
|
gptkb:B-Raf_protein
|
|
gptkbp:Entrez_Gene_ID
|
673
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:foundIn
|
gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:function
|
protein kinase activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasParalog
|
gptkb:ARAF
gptkb:RAF1
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:1097
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
BRAF (gene)
|
|
gptkbp:involves
|
gptkb:MAPK/ERK_pathway
|
|
gptkbp:length
|
18 exons
|
|
gptkbp:locatedOnChromosome
|
7
|
|
gptkbp:mutationAssociatedWith
|
gptkb:V600K
G469A
V600E
|
|
gptkbp:OMIM
|
164757
|
|
gptkbp:orthologInMouse
|
gptkb:Braf
|
|
gptkbp:orthologInZebrafish
|
braf
|
|
gptkbp:regulates
|
apoptosis
differentiation
cellular senescence
cell division
cell growth
MAP kinase activity
|
|
gptkbp:targetOfDrug
|
gptkb:encorafenib
gptkb:dabrafenib
gptkb:vemurafenib
|
|
gptkbp:UniProtID
|
gptkb:P15056
|
|
gptkbp:bfsParent
|
gptkb:164757_(BRAF)
|
|
gptkbp:bfsLayer
|
6
|