|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:B-RAF
gptkb:B-raf_proto-oncogene_serine/threonine-protein_kinase
|
|
gptkbp:associatedWith
|
gptkb:cancer
colorectal cancer
melanoma
|
|
gptkbp:discoveredBy
|
Marx et al.
|
|
gptkbp:discoveredIn
|
2002
|
|
gptkbp:encodedBy
|
gptkb:BRAF_gene
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.1
|
|
gptkbp:function
|
serine/threonine-protein kinase activity
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
BRAF protein
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_signaling_pathway
|
|
gptkbp:locatedOnChromosome
|
gptkb:7q34
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
84 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:V600K
G469A
V600E
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Braf_(mouse)
|
|
gptkbp:PDB
|
gptkb:1UWH
|
|
gptkbp:phosphorylates
|
gptkb:MAP2K1
gptkb:MAP2K2
|
|
gptkbp:structure
|
contains Ras-binding domain
contains protein kinase domain
|
|
gptkbp:target
|
gptkb:encorafenib
gptkb:dabrafenib
gptkb:vemurafenib
|
|
gptkbp:UniProtID
|
gptkb:P15056
|
|
gptkbp:bfsParent
|
gptkb:Ser602_(BRAF)
gptkb:Thr599_(BRAF)
|
|
gptkbp:bfsLayer
|
6
|