Activity-regulated cytoskeleton-associated protein

URI: https://gptkb.org/entity/Activity-regulated_cytoskeleton-associated_protein

GPTKB entity

Statements (61)

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:abbreviation	gptkb:ARC
gptkbp:degradedBy	ubiquitin-proteasome system
gptkbp:discoveredBy	gptkb:Paul_Worley
gptkbp:discoveredIn	1995
gptkbp:Entrez_Gene_ID	ENSG00000198502
gptkbp:expressedIn	activity-dependent high in hippocampus high in cortex high in striatum
gptkbp:foundIn	gptkb:Mus_musculus gptkb:Homo_sapiens
gptkbp:function	gptkb:synaptic_plasticity memory formation regulation of synaptic strength
gptkbp:gene	gptkb:ARC_gene
gptkbp:HGNC_ID	HGNC:651
https://www.w3.org/2000/01/rdf-schema#label	Activity-regulated cytoskeleton-associated protein
gptkbp:inducedBy	neuronal activity
gptkbp:interactsWith	gptkb:AMPA_receptor gptkb:NMDA_receptor gptkb:F-actin gptkb:PSD-95 gptkb:dynamin gptkb:CAMKII gptkb:endophilin
gptkbp:involvedIn	drug addiction learning and memory neuronal signaling fear memory homeostatic plasticity synaptic tagging
gptkbp:locatedOnChromosome	gptkb:8q24.3
gptkbp:location	neurons postsynaptic density dendrites
gptkbp:molecularWeight	45 kDa
gptkbp:orthologIn	Drosophila dArc1 Drosophila dArc2 mouse Arc
gptkbp:regulates	gptkb:CREB gptkb:SRF gptkb:NPAS4 gptkb:BDNF gptkb:Egr1 actin cytoskeleton dendritic spine morphology MEF2
gptkbp:relatedTo	gptkb:Alzheimer's_disease gptkb:autism_spectrum_disorder gptkb:long-term_potentiation neuropsychiatric disorders AMPA receptor trafficking synaptic scaling
gptkbp:structure	forms virus-like capsids contains coiled-coil domain
gptkbp:transportation	gptkb:gene
gptkbp:UniProtID	gptkb:Q7LC44
gptkbp:bfsParent	gptkb:Arc_protein gptkb:Arc_gene
gptkbp:bfsLayer	8