|
gptkbp:instanceOf
|
ionotropic glutamate receptor
|
|
gptkbp:alsoKnownAs
|
α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
|
|
gptkbp:discoveredBy
|
gptkb:John_W._Olney
|
|
gptkbp:drugClass
|
excitatory amino acid receptor
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:autism_spectrum_disorder
epilepsy
schizophrenia
neurodegenerative diseases
|
|
gptkbp:encodedBy
|
gptkb:GRIA1
gptkb:GRIA2
gptkb:GRIA3
gptkb:GRIA4
|
|
gptkbp:enemyOf
|
gptkb:AMPA
gptkb:CNQX
gptkb:NBQX
|
|
gptkbp:firstDescribed
|
1980s
|
|
gptkbp:foundIn
|
central nervous system
|
|
gptkbp:function
|
mediates fast synaptic transmission in the CNS
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
AMPA receptor
|
|
gptkbp:insertedBy
|
exocytosis
|
|
gptkbp:involvedIn
|
gptkb:synaptic_plasticity
gptkb:long-term_potentiation
learning and memory
|
|
gptkbp:ligand
|
glutamate
|
|
gptkbp:locale
|
postsynaptic membrane
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_11_(GRIA3)
gptkb:chromosome_20_(GRIA4)
gptkb:chromosome_4_(GRIA2)
gptkb:chromosome_5_(GRIA1)
|
|
gptkbp:modulatedBy
|
phosphorylation
RNA editing
auxiliary proteins
|
|
gptkbp:permeableTo
|
K+
Na+
|
|
gptkbp:regulates
|
gptkb:GSG1L
gptkb:TARPs
gptkb:cornichon_proteins
CKAMP44
|
|
gptkbp:relatedTo
|
gptkb:NMDA_receptor
gptkb:kainate_receptor
|
|
gptkbp:removes
|
endocytosis
|
|
gptkbp:sometimesPermeableTo
|
Ca2+
|
|
gptkbp:structure
|
tetramer
|
|
gptkbp:subunit
|
gptkb:GluA1
gptkb:GluA2
gptkb:GluA3
gptkb:GluA4
|
|
gptkbp:target
|
anticonvulsants
antidepressants
nootropic drugs
|
|
gptkbp:bfsParent
|
gptkb:Glutamate
gptkb:AMBA_family
|
|
gptkbp:bfsLayer
|
6
|