|
gptkbp:instanceOf
|
gptkb:protein
ionotropic glutamate receptor
|
|
gptkbp:activatedBy
|
glutamate
glycine
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
epilepsy
schizophrenia
stroke
excitotoxicity
|
|
gptkbp:blockedIn
|
magnesium ions
|
|
gptkbp:co-agonist
|
gptkb:D-serine
glycine
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:encodedBy
|
gptkb:GRIN1
gptkb:GRIN2A
gptkb:GRIN2B
gptkb:GRIN2C
gptkb:GRIN2D
gptkb:GRIN3A
gptkb:GRIN3B
|
|
gptkbp:enemyOf
|
gptkb:memantine
gptkb:ketamine
gptkb:phencyclidine
gptkb:aspartate
gptkb:N-methyl-D-aspartate
gptkb:dizocilpine
glutamate
|
|
gptkbp:foundIn
|
central nervous system
|
|
gptkbp:function
|
mediates excitatory synaptic transmission
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NMDA receptor
|
|
gptkbp:location
|
postsynaptic membrane
|
|
gptkbp:modulatedBy
|
gptkb:protons
zinc
polyamines
redox agents
|
|
gptkbp:namedAfter
|
gptkb:N-methyl-D-aspartate
|
|
gptkbp:permeableTo
|
calcium ions
potassium ions
sodium ions
|
|
gptkbp:role
|
gptkb:synaptic_plasticity
learning
memory formation
|
|
gptkbp:structure
|
tetramer
|
|
gptkbp:subunit
|
gptkb:NR2A
gptkb:NR2B
gptkb:NR2C
gptkb:NR2D
gptkb:NR3A
gptkb:NR3B
NR1
|
|
gptkbp:bfsParent
|
gptkb:Glutamate
gptkb:AMBA_family
gptkb:Para-Methoxy_Ketamine
|
|
gptkbp:bfsLayer
|
6
|