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gptkbp:instanceOf
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gptkb:protein
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gptkbp:abbreviation
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Calcium/calmodulin-dependent protein kinase II
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gptkbp:activatedBy
|
calcium/calmodulin
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gptkbp:autophosphorylation
|
Thr286 (alpha subunit)
Thr287 (beta, gamma, delta subunits)
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gptkbp:discoveredBy
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gptkb:Howard_Schulman
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gptkbp:discoveredIn
|
1980s
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gptkbp:EC_number
|
2.7.11.17
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gptkbp:encodedBy
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gptkb:CAMK2D
CAMK2A
CAMK2B
CAMK2G
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gptkbp:foundIn
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gptkb:skeletal_muscle
brain
heart
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gptkbp:fullName
|
Calcium/calmodulin-dependent protein kinase II
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gptkbp:function
|
phosphorylation of proteins
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|
https://www.w3.org/2000/01/rdf-schema#label
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CAMKII
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gptkbp:inhibitedBy
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gptkb:KN-93
KN-62
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gptkbp:locale
|
postsynaptic density
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gptkbp:locatedOnChromosome
|
chromosome 10 (CAMK2G)
chromosome 4 (CAMK2D)
chromosome 5 (CAMK2A)
chromosome 7 (CAMK2B)
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gptkbp:molecularWeight
|
50-60 kDa (per subunit)
|
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gptkbp:oligomerization
|
dodecamer
tetradecamer
|
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gptkbp:PDB
|
2UX0
|
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gptkbp:phosphorylates
|
gptkb:CREB
gptkb:AMPA_receptor
gptkb:phospholamban
gptkb:synapsin_I
|
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gptkbp:relatedTo
|
gptkb:Alzheimer's_disease
gptkb:arrhythmia
gptkb:autism_spectrum_disorder
gptkb:long-term_potentiation
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gptkbp:role
|
gptkb:synaptic_plasticity
memory
learning
|
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gptkbp:structure
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gptkb:holoenzyme
|
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gptkbp:subunit
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gptkb:government_agency
alpha
beta
gamma
|
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gptkbp:UniProtID
|
Q13557
Q13554
Q13555
Q9UQM7
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gptkbp:bfsParent
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gptkb:MEF2C
|
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gptkbp:bfsLayer
|
7
|