APP (amyloid precursor protein)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alternativeSplicing	yes
gptkbp:associatedWith	gptkb:Alzheimer's_disease
gptkbp:cleavage	gptkb:alpha-secretase gptkb:beta-secretase gptkb:gamma-secretase
gptkbp:discoveredBy	Kang et al.
gptkbp:discoveredIn	1987
gptkbp:encodedBy	gptkb:APP_gene
gptkbp:expressedIn	gptkb:skeletal_muscle brain many tissues
gptkbp:foundIn	gptkb:Mus_musculus gptkb:Homo_sapiens
gptkbp:function	cell surface receptor cell adhesion precursor of amyloid beta
gptkbp:hasIsoform	gptkb:APP695 gptkb:APP751 gptkb:APP770
https://www.w3.org/2000/01/rdf-schema#label	APP (amyloid precursor protein)
gptkbp:interactsWith	gptkb:BACE1 gptkb:presenilin-1 gptkb:APLP1 gptkb:APLP2 gptkb:Fe65 gptkb:nicastrin gptkb:X11
gptkbp:length	695-770 amino acids (isoforms)
gptkbp:locatedOnChromosome	chromosome 21 21q21.3
gptkbp:molecularWeight	~100-140 kDa
gptkbp:mutationAssociatedWith	gptkb:familial_Alzheimer's_disease cerebral amyloid angiopathy
gptkbp:OMIM	104760
gptkbp:orthologIn	present in mammals
gptkbp:PDB	3UMH
gptkbp:postTranslationalModification	palmitoylation phosphorylation glycosylation
gptkbp:product	gptkb:amyloid_beta_peptide soluble APP alpha soluble APP beta
gptkbp:relatedTo	gptkb:Down_syndrome gptkb:synaptic_plasticity neuronal development
gptkbp:subcellularLocation	gptkb:endoplasmic_reticulum gptkb:lysosome gptkb:endosome gptkb:Golgi_apparatus gptkb:plasma_membrane
gptkbp:transmembraneDomains	yes
gptkbp:UniProtID	gptkb:P05067
gptkbp:bfsParent	gptkb:Alzheimer's_disease_pathway
gptkbp:bfsLayer	7