Statements (21)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:associatedWith |
non-amyloidogenic pathway
|
| gptkbp:EC_number |
3.4.24.11
|
| gptkbp:example |
gptkb:ADAM17
ADAM10 |
| gptkbp:foundIn |
neurons
other tissues |
| gptkbp:function |
cleaves amyloid precursor protein (APP)
|
| https://www.w3.org/2000/01/rdf-schema#label |
alpha-secretase
|
| gptkbp:memberOf |
ADAM family
|
| gptkbp:prevention |
amyloid-beta peptide formation
|
| gptkbp:product |
soluble APP-alpha (sAPPĪ±)
|
| gptkbp:requires |
zinc
|
| gptkbp:role |
gptkb:Alzheimer's_disease
|
| gptkbp:substrate |
amyloid precursor protein (APP)
|
| gptkbp:type |
metalloprotease
|
| gptkbp:bfsParent |
gptkb:APP_(amyloid_precursor_protein)
gptkb:APP_gene gptkb:Amyloid_Precursor_Protein gptkb:amyloid_precursor_protein |
| gptkbp:bfsLayer |
8
|