Alzheimer's disease pathway

URI: https://gptkb.org/entity/Alzheimer's_disease_pathway

GPTKB entity

Statements (90)

Predicate	Object
gptkbp:instanceOf	biological pathway
gptkbp:containsGene	gptkb:SLC6A4 gptkb:MEF2C gptkb:SLC25A13 gptkb:SLC18A2 gptkb:SLC22A4 gptkb:APOE gptkb:APP gptkb:ABCA7 gptkb:BACE1 gptkb:BIN1 gptkb:CASS4 gptkb:CD2AP gptkb:CD33 gptkb:CELF1 gptkb:CR1 gptkb:CUGBP2 gptkb:DSG2 gptkb:EPHA1 gptkb:FERMT2 gptkb:HLA-DRB5 gptkb:INPP5D gptkb:MS4A6A gptkb:NME8 gptkb:PICALM gptkb:PLD3 gptkb:PSEN1 gptkb:PSEN2 gptkb:PTK2B gptkb:SLC10A2 gptkb:SLC12A5 gptkb:SLC17A7 gptkb:SLC24A4 gptkb:SLC25A12 gptkb:SLC25A14 gptkb:SLC25A15 gptkb:SLC25A16 gptkb:SLC25A17 gptkb:SLC25A18 gptkb:SLC25A19 gptkb:SLC25A20 gptkb:SLC25A21 gptkb:SLC25A22 gptkb:SLC25A23 gptkb:SLC25A24 gptkb:SLC25A25 gptkb:SLC25A26 gptkb:SLC25A27 gptkb:SLC25A28 gptkb:SLC25A29 gptkb:SLC25A30 gptkb:SLC25A31 gptkb:SLC25A32 gptkb:SLC25A33 gptkb:SLC25A34 gptkb:SLC25A35 gptkb:SLC25A36 gptkb:SLC25A37 gptkb:SLC25A38 gptkb:SLC8A1 gptkb:SORL1 gptkb:TREM2 gptkb:ZCWPW1 gptkb:CLU gptkb:MAPT gptkb:SLC9A3R1 gptkb:SLC6A3
gptkbp:foundIn	gptkb:human gptkb:mouse
gptkbp:hasWikiPathwaysID	WP2449
https://www.w3.org/2000/01/rdf-schema#label	Alzheimer's disease pathway
gptkbp:involves	gptkb:tau_protein gptkb:APP_(amyloid_precursor_protein) gptkb:amyloid-beta gptkb:presenilin-1 gptkb:presenilin-2 neurofibrillary tangles oxidative stress astrocyte activation cholinergic deficit microglia activation neuroinflammation secretase enzymes senile plaques synaptic dysfunction
gptkbp:KEGGID	hsa05010
gptkbp:Reactome	R-HSA-399997
gptkbp:relatedTo	gptkb:Alzheimer's_disease
gptkbp:bfsParent	gptkb:APOE_gene
gptkbp:bfsLayer	6