|
gptkbp:instanceOf
|
peptide
|
|
gptkbp:aggregatesInto
|
fibrils
oligomers
|
|
gptkbp:alsoKnownAs
|
gptkb:Aβ
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
|
|
gptkbp:cleavage
|
gptkb:amyloid_precursor_protein
|
|
gptkbp:degradedBy
|
gptkb:neprilysin
gptkb:insulin-degrading_enzyme
|
|
gptkbp:detects
|
PET imaging
cerebrospinal fluid analysis
|
|
gptkbp:discoveredBy
|
gptkb:George_Glenner
|
|
gptkbp:discoveredIn
|
1984
|
|
gptkbp:encodedBy
|
gptkb:APP_gene
|
|
gptkbp:firstDescribed
|
gptkb:Science_journal
|
|
gptkbp:form
|
amyloid plaques
|
|
gptkbp:foundIn
|
gptkb:human
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
amyloid beta peptide
|
|
gptkbp:involvedIn
|
inflammation
oxidative stress
synaptic dysfunction
|
|
gptkbp:involves
|
neurodegeneration
|
|
gptkbp:length
|
36-43 amino acids
|
|
gptkbp:mainIsoforms
|
gptkb:Aβ40
gptkb:Aβ42
|
|
gptkbp:presentIn
|
senile plaques
|
|
gptkbp:producedBy
|
proteolytic cleavage
|
|
gptkbp:sequence
|
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
|
|
gptkbp:solubility
|
poorly soluble
|
|
gptkbp:structure
|
beta sheet
|
|
gptkbp:target
|
Alzheimer's disease therapies
|
|
gptkbp:toxicity
|
neurons
|
|
gptkbp:bfsParent
|
gptkb:Amyloid_beta_A4_protein
gptkb:amyloid_beta_plaques
|
|
gptkbp:bfsLayer
|
7
|