|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:PI3K
phosphorylation
|
|
gptkbp:alsoKnownAs
|
gptkb:Protein_kinase_B
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
gptkb:diabetes
|
|
gptkbp:discoveredBy
|
gptkb:Staal_et_al.
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:encodedBy
|
gptkb:AKT1
gptkb:AKT2
gptkb:AKT3
|
|
gptkbp:function
|
serine/threonine kinase activity
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
AKT kinase
|
|
gptkbp:inhibitedBy
|
gptkb:AZD5363
gptkb:MK-2206
gptkb:triciribine
perifosine
|
|
gptkbp:involvedIn
|
gptkb:PI3K/AKT_signaling_pathway
|
|
gptkbp:locale
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:locatedOnChromosome
|
chromosome 1 (AKT3)
chromosome 14 (AKT1)
chromosome 19 (AKT2)
|
|
gptkbp:molecularWeight
|
~56 kDa
|
|
gptkbp:phosphorylates
|
gptkb:PRAS40
gptkb:TSC2
gptkb:CREB
gptkb:BAD
gptkb:p21
gptkb:p27
gptkb:FOXO_transcription_factors
gptkb:GSK3
gptkb:MDM2
gptkb:mTOR
gptkb:eNOS
IKKα
TBC1D4
AS160
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
cell survival
cell growth
glucose metabolism
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Rattus_norvegicus
|
|
gptkbp:structure
|
contains PH domain
contains kinase domain
contains regulatory domain
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:UniProtID
|
P31749 (AKT1)
P31751 (AKT2)
Q9Y243 (AKT3)
|
|
gptkbp:bfsParent
|
gptkb:FOXO6
|
|
gptkbp:bfsLayer
|
7
|