transformation related protein 53

URI: https://gptkb.org/entity/transformation_related_protein_53
GPTKB entity
Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alsoKnownAs gptkb:p53
gptkbp:degradedBy gptkb:MDM2
gptkbp:discoveredBy gptkb:Arnold_Levine
gptkb:Lloyd_Old
gptkb:David_Lane
gptkbp:discoveredIn 1979
gptkbp:encodedBy gptkb:TP53_gene
gptkbp:Entrez_Gene_ID 7157
ENSG00000141510
gptkbp:expressedIn gptkb:nucleus
gptkb:cytoplasm
gptkbp:function tumor suppressor
transcription factor
https://www.w3.org/2000/01/rdf-schema#label transformation related protein 53
gptkbp:locatedOnChromosome 17p13.1
gptkbp:molecularWeight 53 kDa
gptkbp:mutationAssociatedWith gptkb:cancer
gptkb:Li-Fraumeni_syndrome
gptkbp:OMIM 191170
gptkbp:orthologIn gptkb:mouse
gptkb:zebrafish
gptkb:Drosophila_melanogaster
gptkbp:PDB 1TUP
gptkbp:phosphorylates gptkb:ATR
gptkb:CHK2
ATM
CHK1
gptkbp:postTranslationalModification phosphorylation
methylation
sumoylation
ubiquitination
acetylation
gptkbp:regulates gptkb:BAX
gptkb:GADD45
gptkb:NOXA
gptkb:PUMA
gptkb:p21
gptkb:MDM2
apoptosis
DNA repair
cell cycle
senescence
genomic stability
gptkbp:role DNA damage response
cellular stress response
gptkbp:species gptkb:Homo_sapiens
gptkbp:structure tetramer
gptkbp:UniProtID P04637
gptkbp:bfsParent gptkb:Trp53
gptkbp:bfsLayer 7