|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:catalyzes
|
phosphorylation of tyrosine residues
|
|
gptkbp:discoveredBy
|
gptkb:Tony_Hunter
|
|
gptkbp:discoveredIn
|
1979
|
|
gptkbp:domain
|
kinase domain
SH2 domain
SH3 domain
|
|
gptkbp:EC_number
|
2.7.10.-
|
|
gptkbp:example
|
gptkb:EGFR
gptkb:Insulin_receptor
gptkb:Src
gptkb:JAK
gptkb:Abl
|
|
gptkbp:foundIn
|
eukaryotes
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
protein tyrosine kinases
|
|
gptkbp:inhibitedBy
|
gptkb:alectinib
gptkb:brigatinib
gptkb:ceritinib
gptkb:crizotinib
gptkb:lorlatinib
gptkb:ruxolitinib
gptkb:afatinib
gptkb:erlotinib
gptkb:gefitinib
gptkb:osimertinib
gptkb:tofacitinib
gptkb:bosutinib
gptkb:dasatinib
gptkb:ponatinib
gptkb:baricitinib
gptkb:sorafenib
gptkb:entrectinib
gptkb:cabozantinib
gptkb:pralsetinib
gptkb:selpercatinib
gptkb:vandetanib
gptkb:imatinib
gptkb:pazopanib
gptkb:regorafenib
gptkb:sunitinib
gptkb:lapatinib
gptkb:neratinib
gptkb:lenvatinib
gptkb:axitinib
gptkb:nintedanib
|
|
gptkbp:involvedIn
|
cell differentiation
cell division
cell growth
cell signaling
cancer development
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
colorectal cancer
leukemia
|
|
gptkbp:product
|
gptkb:ADP
phosphorylated protein
|
|
gptkbp:regulates
|
phosphorylation
protein-protein interactions
dephosphorylation
ligand binding
|
|
gptkbp:requires
|
gptkb:ATP
|
|
gptkbp:subclassOf
|
protein kinases
|
|
gptkbp:target
|
tyrosine kinase inhibitors
|
|
gptkbp:bfsParent
|
gptkb:protein_tyrosine_phosphatases
|
|
gptkbp:bfsLayer
|
6
|