neurotrophic tyrosine kinase receptor type 2

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alsoKnownAs	gptkb:TrkB gptkb:NTRK2
gptkbp:associatedWith	gptkb:cancer gptkb:depression gptkb:autism_spectrum_disorder
gptkbp:biologicalProcess	cell differentiation cell survival signal transduction ATP binding protein kinase activity axon guidance
gptkbp:discoveredBy	gptkb:L.F._Parada
gptkbp:discoveredIn	1991
gptkbp:encodedBy	gptkb:NTRK2_gene
gptkbp:Entrez_Gene_ID	4915
gptkbp:expressedIn	brain peripheral nervous system
gptkbp:function	gptkb:receptor_tyrosine_kinase binds neurotrophins
https://www.w3.org/2000/01/rdf-schema#label	neurotrophic tyrosine kinase receptor type 2
gptkbp:inhibitedBy	gptkb:entrectinib gptkb:larotrectinib
gptkbp:ligand	gptkb:brain-derived_neurotrophic_factor gptkb:neurotrophin-3 gptkb:neurotrophin-4
gptkbp:locatedOnChromosome	gptkb:chromosome_9q21.33
gptkbp:location	gptkb:cell_membrane
gptkbp:mutationAssociatedWith	gptkb:neuroblastoma gptkb:cancer gptkb:glioblastoma
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:orthologIn	gptkb:Mus_musculus gptkb:Rattus_norvegicus
gptkbp:PDB	gptkb:1HCF
gptkbp:role	gptkb:synaptic_plasticity neuronal development neuronal survival memory formation
gptkbp:UniProtID	gptkb:Q16620
gptkbp:bfsParent	gptkb:NTRK2_gene gptkb:TrkB_receptor gptkb:Tropomyosin_receptor_kinase_B
gptkbp:bfsLayer	8