natural killer (NK) cells

URI: https://gptkb.org/entity/natural_killer_(NK)_cells

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:immune_response gptkb:lymphocyte
gptkbp:abbreviation	gptkb:NK_cells
gptkbp:activatedBy	gptkb:interleukin-2 gptkb:interferon-alpha gptkb:interleukin-12
gptkbp:developedBy	common lymphoid progenitor
gptkbp:discoveredBy	gptkb:Rolf_Kiessling
gptkbp:discoveredIn	1975
gptkbp:doNotRequire	MHC restriction antigen presentation
gptkbp:expressedIn	natural cytotoxicity receptors CD94/NKG2 complex
gptkbp:foundIn	blood lymph nodes spleen
gptkbp:function	destroy tumor cells destroy virus-infected cells produce cytokines
gptkbp:involves	gptkb:graft-versus-host_disease autoimmune diseases pregnancy immune tolerance
gptkbp:killBy	gptkb:Fas_ligand gptkb:granzymes gptkb:perforin
gptkbp:marking	gptkb:CD56 CD16 CD3 negative
gptkbp:partOf	innate immune system
gptkbp:produces	gptkb:interferon-gamma gptkb:tumor_necrosis_factor-alpha
gptkbp:recipient	gptkb:NKG2D gptkb:KIR_(killer-cell_immunoglobulin-like_receptor) gptkb:CD94
gptkbp:regulates	activating receptors inhibitory receptors
gptkbp:relatedTo	gptkb:B_cells gptkb:T_cells
gptkbp:role	gptkb:immunotherapy viral immunity immunosurveillance
gptkbp:studiedIn	immunology oncology virology
gptkbp:subspecies	gptkb:CD56bright_NK_cells gptkb:CD56dim_NK_cells
gptkbp:bfsParent	gptkb:Fas_ligand_(FasL)
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	natural killer (NK) cells