|
gptkbp:instanceOf
|
gptkb:protein
cytokine
|
|
gptkbp:alternativeName
|
gptkb:B_cell_stimulatory_factor_2
gptkb:hybridoma/plasmacytoma_growth_factor
gptkb:interferon_beta-2
|
|
gptkbp:associatedWith
|
gptkb:Castleman's_disease
rheumatoid arthritis
systemic juvenile idiopathic arthritis
COVID-19 cytokine storm
|
|
gptkbp:discoveredBy
|
gptkb:Tadamitsu_Kishimoto
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:Entrez_Gene_ID
|
3569
|
|
gptkbp:expressedIn
|
gptkb:T_cells
macrophages
endothelial cells
fibroblasts
|
|
gptkbp:function
|
immune response regulation
B cell maturation
acute phase response
inflammation mediator
|
|
gptkbp:gene
|
gptkb:IL6
|
|
gptkbp:halfLife
|
~1.5 hours
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
human interleukin-6
|
|
gptkbp:inhibitedBy
|
gptkb:glucocorticoids
anti-inflammatory cytokines
|
|
gptkbp:locatedOnChromosome
|
7p15.3
|
|
gptkbp:molecularWeight
|
21–28 kDa
|
|
gptkbp:OMIM
|
147620
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
gptkb:MAPK_pathway
gptkb:PI3K-Akt_pathway
gptkb:JAK/STAT_signaling_pathway
|
|
gptkbp:PDB
|
gptkb:1ALU
|
|
gptkbp:postTranslationalModification
|
disulfide bonds
glycosylation
|
|
gptkbp:recipient
|
gptkb:gp130
IL-6 receptor (IL-6R)
|
|
gptkbp:sequence
|
212 amino acids
|
|
gptkbp:stimulated_by
|
gptkb:IL-1
gptkb:TNF-alpha
bacterial endotoxins
|
|
gptkbp:structure
|
monomeric glycoprotein
|
|
gptkbp:targetOfDrug
|
gptkb:tocilizumab
gptkb:sarilumab
gptkb:siltuximab
|
|
gptkbp:UniProtID
|
gptkb:P05231
|
|
gptkbp:bfsParent
|
gptkb:virus
|
|
gptkbp:bfsLayer
|
5
|