Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
cytokine
|
| gptkbp:abbreviation |
gptkb:IL-6
|
| gptkbp:alsoKnownAs |
gptkb:Interleukin-6
|
| gptkbp:discoveredIn |
1980s
|
| gptkbp:encodedBy |
gptkb:IL6_gene
|
| gptkbp:function |
acts as a pro-inflammatory cytokine
induces immunoglobulin production involved in acute phase response stimulates B cell differentiation |
| https://www.w3.org/2000/01/rdf-schema#label |
B cell stimulatory factor 2
|
| gptkbp:involves |
gptkb:cancer
autoimmune diseases inflammatory diseases rheumatoid arthritis COVID-19 cytokine storm |
| gptkbp:locatedOnChromosome |
chromosome 7p15.3
|
| gptkbp:molecularWeight |
21 kDa
|
| gptkbp:producedBy |
gptkb:T_cells
macrophages endothelial cells fibroblasts |
| gptkbp:recipient |
gptkb:IL-6_receptor
|
| gptkbp:structure |
four-helix bundle
|
| gptkbp:target |
gptkb:tocilizumab
gptkb:sarilumab |
| gptkbp:UniProtID |
gptkb:P05231
|
| gptkbp:bfsParent |
gptkb:interleukin-6
gptkb:human_interleukin-6 |
| gptkbp:bfsLayer |
6
|