Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
hormone
class of corticosteroids |
| gptkbp:affects |
central nervous system
lipid metabolism cardiovascular system bone metabolism protein catabolism water and electrolyte balance |
| gptkbp:biosynthesized_from |
cholesterol
|
| gptkbp:category |
gptkb:pharmacy
immunology endocrinology |
| gptkbp:chemicalFormula |
cyclopentanoperhydrophenanthrene ring
|
| gptkbp:discoveredBy |
gptkb:Edward_Calvin_Kendall
gptkb:Tadeus_Reichstein gptkb:Philip_S._Hench |
| gptkbp:example |
gptkb:prednisone
gptkb:dexamethasone cortisol hydrocortisone |
| https://www.w3.org/2000/01/rdf-schema#label |
glucocorticoids
|
| gptkbp:improves |
blood glucose
|
| gptkbp:influenced |
immune response
stress response |
| gptkbp:mechanismOfAction |
bind to glucocorticoid receptor
|
| gptkbp:NobelPrizeYear |
1950 Nobel Prize in Physiology or Medicine
|
| gptkbp:producedBy |
adrenal cortex
|
| gptkbp:regulates |
metabolism of carbohydrates
metabolism of fats metabolism of proteins adrenocorticotropic hormone (ACTH) |
| gptkbp:sideEffect |
gptkb:bone
gptkb:Cushing's_syndrome immunosuppression hypertension hyperglycemia |
| gptkbp:suppressedBy |
inflammation
immune system ACTH secretion adrenal androgen production |
| gptkbp:usedFor |
immunosuppression
anti-inflammatory therapy treatment of asthma treatment of autoimmune diseases treatment of allergies treatment of adrenal insufficiency |
| gptkbp:bfsParent |
gptkb:congenital_adrenal_hyperplasia
gptkb:lipoprotein_lipase gptkb:human_interleukin-6 |
| gptkbp:bfsLayer |
6
|