|
gptkbp:instanceOf
|
gptkb:protein
gptkb:serine_protease
|
|
gptkbp:alternativeName
|
CTLA3
TSP-1
|
|
gptkbp:cleavage
|
pro-IL-1β
APE1/Ref-1
nucleosome assembly protein SET
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:encodedBy
|
gptkb:GZMA_gene
|
|
gptkbp:Entrez_Gene_ID
|
3001
|
|
gptkbp:enzymeCommissionNumber
|
EC 3.4.21.78
|
|
gptkbp:expressedIn
|
activated cytotoxic lymphocytes
|
|
gptkbp:foundIn
|
gptkb:natural_killer_cells
cytotoxic T lymphocytes
|
|
gptkbp:function
|
induces apoptosis in target cells
cleaves proteins after arginine or lysine residues
|
|
gptkbp:HGNC_ID
|
4706
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
granzyme A
|
|
gptkbp:involvedIn
|
immune response
|
|
gptkbp:locatedOnChromosome
|
chromosome 5q11-q12
|
|
gptkbp:molecularWeight
|
32 kDa
|
|
gptkbp:OMIM
|
140050
|
|
gptkbp:PDB
|
1FQ3
|
|
gptkbp:relatedTo
|
gptkb:granzyme_B
|
|
gptkbp:releaseMechanism
|
exocytosis upon immune synapse formation
|
|
gptkbp:roleInImmunity
|
mediates cell-mediated cytotoxicity
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
contains a serine protease domain
|
|
gptkbp:subcellularLocation
|
cytoplasmic granules
|
|
gptkbp:UniProtID
|
P12544
|
|
gptkbp:bfsParent
|
gptkb:granzymes
|
|
gptkbp:bfsLayer
|
6
|