Statements (90)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
superfamily
|
| gptkbp:alternativeName |
serpin superfamily
serine protease inhibitor superfamily |
| gptkbp:alternativeTo |
some have chaperone activity
some have hormone transport roles some inhibit cysteine proteases |
| gptkbp:associatedWith |
gptkb:alpha-1_antitrypsin_deficiency
emphysema thrombosis liver cirrhosis |
| gptkbp:database |
MEROPS: I4
Pfam: PF00079 Gene Ontology: GO:0004867 InterPro: IPR023796 UniProt: P01009 Wikipedia: Serpin |
| gptkbp:discoveredBy |
gptkb:Hans_Fritz
|
| gptkbp:discoveredIn |
1980s
|
| gptkbp:foundIn |
gptkb:Bacteria
animals plants viruses |
| gptkbp:fullName |
gptkb:serine_protease_inhibitors
|
| gptkbp:function |
inhibit serine proteases
regulate proteolytic pathways |
| https://www.w3.org/2000/01/rdf-schema#label |
serpins
|
| gptkbp:mechanismOfAction |
suicide substrate mechanism
|
| gptkbp:mutationAssociatedWith |
can cause conformational diseases
|
| gptkbp:notableMember |
gptkb:plasminogen_activator_inhibitor-1
gptkb:alpha-1_antitrypsin gptkb:neuroserpin gptkb:C1-inhibitor gptkb:antithrombin_III ovalbumin heparin cofactor II clade B serpins clade C serpins clade D serpins clade E serpins clade F serpins clade G serpins clade H serpins clade I serpins clade K serpins clade L serpins clade M serpins clade N serpins clade O serpins clade P serpins clade Q serpins clade R serpins clade S serpins clade T serpins clade U serpins clade V serpins clade W serpins clade X serpins clade Y serpins clade Z serpins maspin protein C inhibitor |
| gptkbp:proteinFamily |
gptkb:SERPINA
gptkb:SERPINB gptkb:SERPINC gptkb:SERPIND gptkb:SERPINE gptkb:SERPINF SERPING SERPINH SERPINI SERPINK SERPINL SERPINJ SERPINM SERPINO SERPINS SERPINT SERPINU SERPINV SERPINW SERPINX SERPINY SERPINZ |
| gptkbp:relatedTo |
gptkb:plasminogen_activator_inhibitor-1
gptkb:alpha-1_antitrypsin gptkb:antithrombin gptkb:neuroserpin |
| gptkbp:structure |
conserved tertiary structure
|
| gptkbp:bfsParent |
gptkb:granzymes
|
| gptkbp:bfsLayer |
6
|