|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
gptkb:Ras_protein
|
|
gptkbp:alternativeName
|
gptkb:RAF_proto-oncogene_serine/threonine-protein_kinase
gptkb:RAF1
|
|
gptkbp:associatedWith
|
gptkb:LEOPARD_syndrome
gptkb:cancer
gptkb:Noonan_syndrome
|
|
gptkbp:determines
|
X-ray crystallography
|
|
gptkbp:discoveredBy
|
gptkb:Hartmut_Beug
|
|
gptkbp:discoveredIn
|
1983
|
|
gptkbp:domain
|
regulatory domain
protein kinase domain
|
|
gptkbp:encodedBy
|
gptkb:RAF1_gene
|
|
gptkbp:Entrez_Gene_ID
|
5894
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.1
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:formsComplexWith
|
gptkb:14-3-3_proteins
gptkb:CDC37
gptkb:Hsp90
|
|
gptkbp:function
|
serine/threonine-protein kinase activity
|
|
gptkbp:HGNC_ID
|
9829
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
c-Raf
|
|
gptkbp:inhibitedBy
|
gptkb:sorafenib
gptkb:vemurafenib
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_signaling_pathway
|
|
gptkbp:locatedIn
|
gptkb:cell_membrane
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
3p25
|
|
gptkbp:memberOf
|
gptkb:RAF_kinase_family
|
|
gptkbp:molecularWeight
|
74 kDa
|
|
gptkbp:mutationAssociatedWith
|
cancer progression
developmental disorders
|
|
gptkbp:OMIM
|
164760
|
|
gptkbp:orthologIn
|
gptkb:RAF1
|
|
gptkbp:orthologInMouse
|
gptkb:Raf1
|
|
gptkbp:phosphorylates
|
gptkb:MEK1
gptkb:MEK2
Ser259
Ser338
Ser621
Tyr341
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell division
|
|
gptkbp:target
|
anticancer drugs
|
|
gptkbp:UniProtID
|
gptkb:P04049
|
|
gptkbp:bfsParent
|
gptkb:RAF1_protein
gptkb:Raf1
gptkb:M-Ras
|
|
gptkbp:bfsLayer
|
7
|