|
gptkbp:instanceOf
|
gptkb:protein
molecular chaperone
|
|
gptkbp:alias
|
Heat shock protein 90
|
|
gptkbp:ATPaseActivity
|
yes
|
|
gptkbp:clientProtein
|
gptkb:steroid_hormone_receptors
gptkb:kinases
transcription factors
|
|
gptkbp:conservedIn
|
eukaryotes
prokaryotes (as HtpG)
|
|
gptkbp:discoveredBy
|
gptkb:Ferruccio_Ritossa
|
|
gptkbp:discoveredIn
|
1962
|
|
gptkbp:domain
|
middle domain
C-terminal dimerization domain
N-terminal ATP-binding domain
|
|
gptkbp:encodedBy
|
gptkb:HSP90B1_gene
HSP90AA1 gene
HSP90AB1 gene
TRAP1 gene
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:function
|
protein folding
protein degradation
stabilization of proteins
|
|
gptkbp:gene
|
gptkb:HSP90AA1
gptkb:HSP90AB1
gptkb:HSP90B1
gptkb:TRAP1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Hsp90
|
|
gptkbp:inducedBy
|
heat shock
cellular stress
|
|
gptkbp:inhibitedBy
|
gptkb:17-AAG
gptkb:geldanamycin
gptkb:radicicol
|
|
gptkbp:interactsWith
|
co-chaperone Aha1
co-chaperone Cdc37
co-chaperone HOP
co-chaperone p23
|
|
gptkbp:locale
|
gptkb:endoplasmic_reticulum
mitochondria
cytosol
|
|
gptkbp:molecularWeight
|
~90 kDa
|
|
gptkbp:orthologIn
|
HtpG (bacteria)
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:requires
|
cell viability
|
|
gptkbp:role
|
gptkb:cancer
neurodegenerative diseases
cell signaling
stress response
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:target
|
anticancer drugs
antifungal drugs
|
|
gptkbp:bfsParent
|
gptkb:Heat_shock_protein
|
|
gptkbp:bfsLayer
|
6
|