|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:Proto-oncogene_c-Jun
AP-1 transcription factor subunit JUN
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:glioblastoma
liver cancer
osteosarcoma
|
|
gptkbp:biologicalProcess
|
dimerization
DNA binding
|
|
gptkbp:discoveredBy
|
gptkb:Robert_Tjian
|
|
gptkbp:discoveredIn
|
1987
|
|
gptkbp:encodes
|
c-Jun protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:JUN
3725
ENSG00000177606
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:function
|
apoptosis
cell proliferation
differentiation
transcription regulation
|
|
gptkbp:HGNC_ID
|
6204
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
JUN gene
|
|
gptkbp:interactsWith
|
gptkb:FOS_gene
ATF gene
JDP2 protein
|
|
gptkbp:length
|
331 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:1p32-p31
|
|
gptkbp:memberOf
|
AP-1 transcription factor complex
|
|
gptkbp:MIM_number
|
165160
|
|
gptkbp:mutationAssociatedWith
|
tumorigenesis
|
|
gptkbp:OMIM
|
165160
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
Mus musculus (mouse)
Rattus norvegicus (rat)
|
|
gptkbp:product
|
gptkb:c-Jun
|
|
gptkbp:proteinFamily
|
gptkb:basic_leucine_zipper_(bZIP)
|
|
gptkbp:referenceGenome
|
gptkb:GRCh38
|
|
gptkbp:regulates
|
gptkb:MAPK_pathway
gptkb:JNK_pathway
gptkb:TRE_(TPA_response_element)
phosphorylation
inflammation
immune response
cell cycle
ubiquitination
stress response
proteasomal degradation
|
|
gptkbp:UniProtID
|
gptkb:P05412
|
|
gptkbp:bfsParent
|
gptkb:c-Jun
|
|
gptkbp:bfsLayer
|
7
|