|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:VEGFR2
FLK1
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:hereditary_hemorrhagic_telangiectasia
pre-eclampsia
|
|
gptkbp:component
|
integral component of plasma membrane
|
|
gptkbp:discoveredBy
|
Terman et al.
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:encodes
|
vascular endothelial growth factor receptor 2
|
|
gptkbp:Entrez_Gene_ID
|
3791
ENSG00000128052
|
|
gptkbp:expressedIn
|
endothelial cells
|
|
gptkbp:fullName
|
kinase insert domain receptor
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
protein tyrosine kinase activity
regulates angiogenesis
mediates VEGF-induced endothelial proliferation
|
|
gptkbp:GOProcess
|
angiogenesis
|
|
gptkbp:HGNC_ID
|
HGNC:6307
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
KDR gene
|
|
gptkbp:interactsWith
|
gptkb:PLCĪ³
gptkb:SHC1
gptkb:PI3K
gptkb:SRC
gptkb:VEGF-A
gptkb:PTK2B
gptkb:GRB2
gptkb:VEGF-C
gptkb:VEGF-D
neuropilin-1
|
|
gptkbp:length
|
1356 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_4q12
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
151 kDa
|
|
gptkbp:mutationAssociatedWith
|
can lead to vascular malformations
|
|
gptkbp:OMIM
|
191306
|
|
gptkbp:orthologInMouse
|
Flk1
|
|
gptkbp:pathway
|
gptkb:VEGF_signaling_pathway
|
|
gptkbp:phosphorylates
|
tyrosine residues
|
|
gptkbp:regulates
|
upregulated by hypoxia
regulated by VEGF-A
|
|
gptkbp:targetOfDrug
|
gptkb:bevacizumab
gptkb:sorafenib
gptkb:pazopanib
gptkb:sunitinib
|
|
gptkbp:UniProtID
|
P35968
|
|
gptkbp:bfsParent
|
gptkb:VEGFR2
|
|
gptkbp:bfsLayer
|
6
|