|
gptkbp:instanceOf
|
cytokine
|
|
gptkbp:abbreviation
|
gptkb:TNF
|
|
gptkbp:alternativeName
|
gptkb:TNF-alpha
gptkb:cachectin
|
|
gptkbp:associatedWith
|
gptkb:Crohn's_disease
psoriasis
septic shock
rheumatoid arthritis
|
|
gptkbp:category
|
immune system protein
signaling protein
pro-inflammatory cytokine
|
|
gptkbp:discoveredBy
|
gptkb:Lloyd_J._Old
|
|
gptkbp:encodedBy
|
gptkb:TNF_gene
|
|
gptkbp:firstDescribed
|
1975
|
|
gptkbp:function
|
apoptosis
inflammation
inhibition of tumorigenesis
inhibition of viral replication
regulation of immune cells
induction of fever
|
|
gptkbp:gene
|
gptkb:TNF_gene
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Tumor necrosis factor
|
|
gptkbp:inhibitedBy
|
gptkb:thalidomide
gptkb:lenalidomide
pentoxifylline
apremilast
|
|
gptkbp:location
|
gptkb:chromosome_6
|
|
gptkbp:MeSH_ID
|
D014010
|
|
gptkbp:molecularWeight
|
17 kDa (monomer)
|
|
gptkbp:OMIM
|
191160
|
|
gptkbp:orthologIn
|
gptkb:lymphotoxin_alpha
gptkb:lymphotoxin_beta
|
|
gptkbp:pathway
|
gptkb:MAPK_pathway
gptkb:NF-κB_pathway
apoptosis pathway
|
|
gptkbp:producedBy
|
gptkb:natural_killer_cells
gptkb:T_cells
macrophages
|
|
gptkbp:recipient
|
TNF receptor 1
TNF receptor 2
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
trimer
|
|
gptkbp:target
|
gptkb:etanercept
gptkb:golimumab
gptkb:infliximab
gptkb:certolizumab_pegol
gptkb:adalimumab
|
|
gptkbp:UniProtID
|
gptkb:P01375
|
|
gptkbp:bfsParent
|
gptkb:P05362
|
|
gptkbp:bfsLayer
|
8
|