Target of Rapamycin (TOR) protein

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alsoKnownAs	gptkb:mammalian_target_of_rapamycin gptkb:mechanistic_target_of_rapamycin gptkb:mTOR
gptkbp:biologicalProcess	serine/threonine kinase activity
gptkbp:complexity	gptkb:mTORC1 gptkb:mTORC2
gptkbp:discoveredIn	gptkb:yeast
gptkbp:EC_number	2.7.11.1
gptkbp:function	regulation of cell proliferation regulation of cell survival regulation of autophagy regulation of cell growth regulation of cell motility regulation of protein synthesis
gptkbp:gene	gptkb:MTOR
https://www.w3.org/2000/01/rdf-schema#label	Target of Rapamycin (TOR) protein
gptkbp:inhibitedBy	gptkb:everolimus gptkb:rapamycin gptkb:sirolimus gptkb:temsirolimus
gptkbp:locatedOnChromosome	chromosome 1p36.2 (human)
gptkbp:location	gptkb:nucleus gptkb:cytoplasm
gptkbp:organism	eukaryotes
gptkbp:pathway	gptkb:PI3K/AKT/mTOR_pathway
gptkbp:phosphorylates	gptkb:4EBP1 gptkb:S6K1 gptkb:ULK1 gptkb:AKT
gptkbp:regulates	lipid metabolism angiogenesis glucose metabolism immune response autophagy inhibition mitochondrial biogenesis ribosome biogenesis translation initiation
gptkbp:role	gptkb:tuberous_sclerosis gptkb:cancer gptkb:diabetes aging obesity neurodegeneration
gptkbp:upregulatedBy	gptkb:insulin growth factors amino acids oxygen levels energy status
gptkbp:bfsParent	gptkb:TOR_Loop_24 gptkb:TOR_Loop_5 gptkb:TOR_Loop_7
gptkbp:bfsLayer	8