Tumor necrosis factor receptor 2

URI: https://gptkb.org/entity/Tumor_necrosis_factor_receptor_2
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
cell surface receptor
gptkbp:alternativeName gptkb:CD120b
gptkb:TNFR2
gptkb:TNFRSF1B
p75 TNF receptor
gptkbp:associatedWith gptkb:cancer
autoimmune diseases
inflammatory diseases
gptkbp:binds gptkb:tumor_necrosis_factor_alpha
gptkbp:discoveredIn 1990s
gptkbp:encodedBy gptkb:TNFRSF1B_gene
gptkbp:Entrez_Gene_ID 7133
ENSG00000028137
gptkbp:excludes death domain
gptkbp:expressedIn gptkb:thymus
spleen
neurons
endothelial cells
immune cells
lymphoid tissues
gptkbp:foundIn humans
mice
gptkbp:function involved in inflammation
regulates apoptosis
regulates cell survival
mediates immune response
gptkbp:HGNC_ID 11917
https://www.w3.org/2000/01/rdf-schema#label Tumor necrosis factor receptor 2
gptkbp:interactsWith gptkb:TRAF2
gptkb:TRAF1
gptkb:cIAP1
gptkb:cIAP2
gptkbp:length 439 amino acids
gptkbp:locatedOnChromosome human chromosome 1p36.2
gptkbp:memberOf gptkb:tumor_necrosis_factor_receptor_superfamily
gptkbp:molecularWeight 45 kDa
gptkbp:OMIM 191191
gptkbp:PDB gptkb:3ALQ
gptkbp:RefSeq NM_001066
gptkbp:regulates gptkb:MAPK_pathway
gptkb:JNK_pathway
gptkb:NF-kappaB_pathway
gptkbp:structure transmembrane domain
extracellular cysteine-rich domains
intracellular death domain (absent)
gptkbp:target therapeutic antibodies
gptkbp:UniProtID gptkb:P20333
gptkbp:bfsParent gptkb:TNFR2
gptkbp:bfsLayer 7