Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
cytokine
|
| gptkbp:abbreviation |
gptkb:IL-1
|
| gptkbp:composedOf |
interleukin-1 alpha
interleukin-1 beta |
| gptkbp:discoveredBy |
Charles A. Dinarello
|
| gptkbp:function |
mediates inflammatory response
|
| https://www.w3.org/2000/01/rdf-schema#label |
interleukin-1
|
| gptkbp:improves |
leukocyte migration
vascular permeability |
| gptkbp:involvedIn |
gptkb:type_2_diabetes
atherosclerosis gout rheumatoid arthritis |
| gptkbp:locatedOnChromosome |
chromosome 2
|
| gptkbp:producedBy |
macrophages
monocytes |
| gptkbp:promotion |
acute phase protein synthesis
prostaglandin production |
| gptkbp:recipient |
interleukin-1 receptor
|
| gptkbp:relatedTo |
gptkb:interleukin-6
gptkb:tumor_necrosis_factor_alpha |
| gptkbp:role |
apoptosis
cell proliferation sepsis autoimmune diseases immune response fever induction |
| gptkbp:target |
gptkb:canakinumab
gptkb:anakinra rilonacept |
| gptkbp:bfsParent |
gptkb:Macrophage
|
| gptkbp:bfsLayer |
5
|