Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:gene |
| gptkbp:alternativeName |
gptkb:SRC-1
Steroid receptor coactivator-1 |
| gptkbp:associatedWith |
gptkb:cancer
prostate cancer |
| gptkbp:coactivatorFor |
estrogen receptor alpha
estrogen receptor beta thyroid hormone receptor nuclear hormone receptors glucocorticoid receptor progesterone receptor mineralocorticoid receptor vitamin D receptor retinoic acid receptor PPARs |
| gptkbp:discoveredBy |
Bert W. O'Malley
|
| gptkbp:discoveredIn |
1995
|
| gptkbp:domain |
bHLH-PAS domain
LXXLL motif CBP/p300 interaction domain |
| gptkbp:encodedBy |
NCOA1 gene
|
| gptkbp:Entrez_Gene_ID |
8648
|
| gptkbp:fullName |
Nuclear receptor coactivator 1
|
| gptkbp:function |
transcriptional coactivator
enhances transcriptional activation interacts with nuclear hormone receptors |
| gptkbp:interactsWith |
gptkb:androgen_receptor
estrogen receptor glucocorticoid receptor |
| gptkbp:involvedIn |
cancer progression
gene expression regulation hormone signaling |
| gptkbp:locatedOnChromosome |
gptkb:17q12
|
| gptkbp:molecularWeight |
~160 kDa
|
| gptkbp:OMIM |
601305
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologIn |
gptkb:Mus_musculus
gptkb:Rattus_norvegicus |
| gptkbp:PDB |
1OQA
2AZF |
| gptkbp:phosphorylates |
yes
|
| gptkbp:postTranslationalModification |
phosphorylation
ubiquitination acetylation |
| gptkbp:regulates |
transcription
|
| gptkbp:subcellularLocation |
gptkb:nucleus
|
| gptkbp:UniProtID |
Q15788
|
| gptkbp:bfsParent |
gptkb:STAT6
|
| gptkbp:bfsLayer |
8
|
| https://www.w3.org/2000/01/rdf-schema#label |
NCoA-1
|