NCoA-1

GPTKB entity

Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:gene
gptkbp:alternativeName gptkb:SRC-1
Steroid receptor coactivator-1
gptkbp:associatedWith gptkb:cancer
prostate cancer
gptkbp:coactivatorFor estrogen receptor alpha
estrogen receptor beta
thyroid hormone receptor
nuclear hormone receptors
glucocorticoid receptor
progesterone receptor
mineralocorticoid receptor
vitamin D receptor
retinoic acid receptor
PPARs
gptkbp:discoveredBy Bert W. O'Malley
gptkbp:discoveredIn 1995
gptkbp:domain bHLH-PAS domain
LXXLL motif
CBP/p300 interaction domain
gptkbp:encodedBy NCOA1 gene
gptkbp:Entrez_Gene_ID 8648
gptkbp:fullName Nuclear receptor coactivator 1
gptkbp:function transcriptional coactivator
enhances transcriptional activation
interacts with nuclear hormone receptors
https://www.w3.org/2000/01/rdf-schema#label NCoA-1
gptkbp:interactsWith gptkb:androgen_receptor
estrogen receptor
glucocorticoid receptor
gptkbp:involvedIn cancer progression
gene expression regulation
hormone signaling
gptkbp:locatedOnChromosome gptkb:17q12
gptkbp:molecularWeight ~160 kDa
gptkbp:OMIM 601305
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Rattus_norvegicus
gptkbp:PDB 1OQA
2AZF
gptkbp:phosphorylates yes
gptkbp:postTranslationalModification phosphorylation
ubiquitination
acetylation
gptkbp:regulates transcription
gptkbp:subcellularLocation gptkb:nucleus
gptkbp:UniProtID Q15788
gptkbp:bfsParent gptkb:STAT6
gptkbp:bfsLayer 8