|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:abbreviation
|
gptkb:STAT
|
|
gptkbp:activatedBy
|
cytokines
growth factors
|
|
gptkbp:discoveredBy
|
gptkb:James_E._Darnell
|
|
gptkbp:domain
|
SH2 domain
DNA-binding domain
transactivation domain
|
|
gptkbp:firstDescribed
|
1994
|
|
gptkbp:foundIn
|
vertebrates
|
|
gptkbp:fullName
|
Signal Transducer and Activator of Transcription protein family
|
|
gptkbp:function
|
signal transduction
transcription factor
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
STAT protein family
|
|
gptkbp:involves
|
apoptosis
cell growth
immune response
oncogenesis
|
|
gptkbp:locatedOnChromosome
|
various chromosomes
|
|
gptkbp:mechanismOfAction
|
dimerization
phosphorylation
nuclear translocation
|
|
gptkbp:member
|
gptkb:STAT1
gptkb:STAT2
gptkb:STAT4
gptkb:STAT5A
gptkb:STAT5B
gptkb:STAT6
gptkb:STAT3
|
|
gptkbp:mutationAssociatedWith
|
autoimmune diseases
cancers
immunodeficiencies
|
|
gptkbp:orthologIn
|
gptkb:fish
birds
amphibians
mammals
reptiles
|
|
gptkbp:pathway
|
gptkb:JAK-STAT_signaling_pathway
|
|
gptkbp:regulates
|
gene expression
|
|
gptkbp:target
|
biologics
small molecule inhibitors
therapeutic drugs
|
|
gptkbp:bfsParent
|
gptkb:Signal_transducer_and_activator_of_transcription_3
gptkb:STAT4
gptkb:STAT5A
gptkb:STAT5B
gptkb:STAT6
gptkb:STAT1_gene
|
|
gptkbp:bfsLayer
|
8
|