|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:BSF1
gptkb:IL-4
gptkb:interleukin_4
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:atopic_dermatitis
asthma
autoimmune diseases
allergic diseases
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:encodes
|
gptkb:interleukin-4
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000113520
3565
|
|
gptkbp:expressedIn
|
gptkb:basophils
gptkb:mast_cells
gptkb:T_helper_2_cells
|
|
gptkbp:function
|
B cell differentiation
regulation of immune response
class switching to IgE
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
6014
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IL4 gene
|
|
gptkbp:length
|
~10 kb
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_5
5q31.1
|
|
gptkbp:locusType
|
5q31.1
|
|
gptkbp:mutationAssociatedWith
|
gptkb:hyper_IgE_syndrome
susceptibility to asthma
susceptibility to atopy
|
|
gptkbp:numberOfExons
|
4
|
|
gptkbp:OMIM
|
147780
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Il4
|
|
gptkbp:pathway
|
gptkb:JAK-STAT_signaling_pathway
cytokine-cytokine receptor interaction
|
|
gptkbp:product
|
gptkb:interleukin-4
|
|
gptkbp:proteinFamily
|
interleukin gene family
|
|
gptkbp:recipient
|
gptkb:IL-13_receptor_alpha_1
gptkb:IL-4_receptor_alpha
|
|
gptkbp:regulates
|
immunoglobulin class switching
macrophage activation
Th2 cell differentiation
|
|
gptkbp:symbol
|
gptkb:IL4
|
|
gptkbp:transcriptionFactorBinding
|
gptkb:GATA3
gptkb:STAT6
|
|
gptkbp:UniProtID
|
P05112
|
|
gptkbp:bfsParent
|
gptkb:IL4
gptkb:Il-4
|
|
gptkbp:bfsLayer
|
6
|