|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:Signal_transducer_and_activator_of_transcription_3
APRF
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:discoveredBy
|
gptkb:James_E._Darnell_Jr.
|
|
gptkbp:encodes
|
gptkb:Signal_transducer_and_activator_of_transcription_3
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000168610
6774
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:firstDescribed
|
1994
|
|
gptkbp:function
|
signal transduction
transcription factor
|
|
gptkbp:HGNC_ID
|
11364
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
STAT3 gene
|
|
gptkbp:involvedIn
|
gptkb:JAK-STAT_signaling_pathway
apoptosis
cell growth
immune response
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_17
17q21.31
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Hyper-IgE_syndrome
autoimmune diseases
cancers
|
|
gptkbp:OMIM
|
102582
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:phosphorylates
|
gptkb:JAK_kinases
|
|
gptkbp:product
|
STAT3 protein
|
|
gptkbp:regulates
|
gene expression
|
|
gptkbp:relatedTo
|
gptkb:STAT1_gene
STAT5 gene
|
|
gptkbp:target
|
therapeutic inhibitors
|
|
gptkbp:UniProtID
|
gptkb:P40763
|
|
gptkbp:bfsParent
|
gptkb:STAT3
|
|
gptkbp:bfsLayer
|
7
|