Statements (57)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alias |
CIS3
SOCS-3 SSI-3 STAT-induced STAT inhibitor 3 |
| gptkbp:associatedWith |
gptkb:cancer
gptkb:type_2_diabetes obesity |
| gptkbp:discoveredBy |
Yoshimura et al.
|
| gptkbp:discoveredIn |
1997
|
| gptkbp:encodes |
SOCS3 protein
|
| gptkbp:Entrez_Gene_ID |
9021
ENSG00000184557 |
| gptkbp:expressedIn |
liver
adipose tissue immune cells |
| gptkbp:fullName |
Suppressor of cytokine signaling 3
|
| gptkbp:function |
negative regulation of cytokine signaling
inhibition of JAK/STAT pathway |
| gptkbp:HGNC_ID |
HGNC:19391
|
| https://www.w3.org/2000/01/rdf-schema#label |
SOCS3
|
| gptkbp:inhibitedBy |
gptkb:JAK2
gptkb:STAT3 |
| gptkbp:length |
225 amino acids
|
| gptkbp:locatedOnChromosome |
17q25.3
|
| gptkbp:molecularWeight |
24.7 kDa
|
| gptkbp:mutationAssociatedWith |
gptkb:metabolic_syndrome
autoimmune diseases inflammatory diseases |
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
Socs3
|
| gptkbp:phosphorylates |
Serine 53
Tyrosine 221 |
| gptkbp:proteinFamily |
gptkb:SOCS_box
SH2 domain |
| gptkbp:regulates |
cell proliferation
inflammation immune response insulin resistance interferon signaling insulin signaling growth hormone signaling erythropoiesis macrophage activation hematopoiesis adipogenesis leptin signaling T cell differentiation interleukin-6 signaling |
| gptkbp:UniProtID |
O14543
|
| gptkbp:bfsParent |
gptkb:SOCS
gptkb:SOCS_family gptkb:gp130 gptkb:SOCS_proteins gptkb:Cish_(mouse_gene) gptkb:STAT3 |
| gptkbp:bfsLayer |
7
|