Signal transducer and activator of transcription 3

URI: https://gptkb.org/entity/Signal_transducer_and_activator_of_transcription_3
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation gptkb:STAT3
gptkbp:activatedBy cytokines
growth factors
phosphorylation
gptkbp:alternativeSplicing produces STAT3α and STAT3β isoforms
gptkbp:associatedWith gptkb:cancer
autoimmune diseases
inflammation
gptkbp:discoveredBy gptkb:James_E._Darnell
gptkbp:discoveredIn 1994
gptkbp:encodedBy gptkb:STAT3_gene
gptkbp:Entrez_Gene_ID gptkb:ENSG00000168610
gptkb:STAT3
6774
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function signal transduction
transcription factor
gptkbp:HGNC_ID 11364
https://www.w3.org/2000/01/rdf-schema#label Signal transducer and activator of transcription 3
gptkbp:inhibitedBy gptkb:SOCS3
gptkb:PIAS3
gptkb:S3I-201
gptkb:Stattic
gptkbp:interactsWith gptkb:JAK2
gptkb:EGFR
gptkb:PIAS3
gptkb:SRC
gptkb:JAK1
gptkb:GRB2
gptkbp:involvedIn gptkb:JAK-STAT_signaling_pathway
gptkbp:locale gptkb:nucleus
gptkb:cytoplasm
gptkbp:locatedOnChromosome gptkb:17q21
gptkbp:memberOf gptkb:STAT_protein_family
gptkbp:molecularWeight 88 kDa
gptkbp:OMIM 102582
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Rattus_norvegicus
gptkbp:PDB gptkb:1BG1
gptkbp:phosphorylates serine 727
tyrosine 705
gptkbp:regulates apoptosis
cell growth
immune response
gptkbp:target therapeutic inhibitors
gptkbp:UniProtID gptkb:P40763
gptkbp:bfsParent gptkb:STAT3
gptkbp:bfsLayer 7