Signal transducer and activator of transcription 3

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:abbreviation	gptkb:STAT3
gptkbp:activatedBy	cytokines growth factors phosphorylation
gptkbp:alternativeSplicing	produces STAT3α and STAT3β isoforms
gptkbp:associatedWith	gptkb:cancer autoimmune diseases inflammation
gptkbp:discoveredBy	gptkb:James_E._Darnell
gptkbp:discoveredIn	1994
gptkbp:encodedBy	gptkb:STAT3_gene
gptkbp:Entrez_Gene_ID	gptkb:ENSG00000168610 gptkb:STAT3 6774
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	gptkb:transcription_factor signal transduction
gptkbp:HGNC_ID	11364
gptkbp:inhibitedBy	gptkb:SOCS3 gptkb:PIAS3 gptkb:S3I-201 gptkb:Stattic
gptkbp:interactsWith	gptkb:JAK2 gptkb:EGFR gptkb:PIAS3 gptkb:SRC gptkb:JAK1 gptkb:GRB2
gptkbp:involvedIn	gptkb:JAK-STAT_signaling_pathway
gptkbp:locale	gptkb:nucleus gptkb:cytoplasm
gptkbp:locatedOnChromosome	gptkb:17q21
gptkbp:memberOf	gptkb:STAT_protein_family
gptkbp:molecularWeight	88 kDa
gptkbp:OMIM	102582
gptkbp:orthologIn	gptkb:Mus_musculus gptkb:Rattus_norvegicus
gptkbp:PDB	gptkb:1BG1
gptkbp:phosphorylates	serine 727 tyrosine 705
gptkbp:regulates	gptkb:immune_response apoptosis cell growth
gptkbp:target	therapeutic inhibitors
gptkbp:UniProtID	gptkb:P40763
gptkbp:bfsParent	gptkb:STAT3
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	Signal transducer and activator of transcription 3