|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:RAS_protein
|
|
gptkbp:alternativeName
|
gptkb:Rapidly_Accelerated_Fibrosarcoma_kinase
|
|
gptkbp:associatedWith
|
gptkb:cancer
melanoma
|
|
gptkbp:contains
|
gptkb:CR1_domain
gptkb:CR2_domain
gptkb:CR3_domain
|
|
gptkbp:discoveredBy
|
gptkb:Werner_Kirsten
gptkb:Wolfgang_D._Rouslahti
|
|
gptkbp:encodedBy
|
gptkb:RAF_gene_family
|
|
gptkbp:firstDescribed
|
1983
|
|
gptkbp:function
|
serine/threonine-protein kinase activity
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RAF kinase
|
|
gptkbp:includes
|
gptkb:ARAF
gptkb:BRAF
gptkb:CRAF
|
|
gptkbp:inhibitedBy
|
gptkb:dabrafenib
gptkb:sorafenib
gptkb:vemurafenib
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_signaling_pathway
|
|
gptkbp:locale
|
gptkb:cell_membrane
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
gptkb:3p25_(CRAF)
gptkb:7q34_(BRAF)
gptkb:X_chromosome_(ARAF)
|
|
gptkbp:memberOf
|
gptkb:protein_kinase_superfamily
|
|
gptkbp:mutationAssociatedWith
|
gptkb:BRAF_V600E
|
|
gptkbp:OMIM
|
gptkb:164757_(BRAF)
gptkb:164761_(CRAF)
gptkb:311010_(ARAF)
|
|
gptkbp:orthologIn
|
gptkb:Caenorhabditis_elegans_(lin-45)
gptkb:Drosophila_melanogaster_(D-raf)
|
|
gptkbp:phosphorylates
|
gptkb:MEK
gptkb:Ser338_(CRAF)
gptkb:Ser602_(BRAF)
gptkb:Thr599_(BRAF)
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
autoinhibition
cell division
dimerization
phosphorylation
|
|
gptkbp:structure
|
kinase domain
regulatory domain
|
|
gptkbp:target
|
kinase inhibitors
|
|
gptkbp:UniProtID
|
gptkb:P10398_(ARAF)
P04049 (BRAF)
P15056 (CRAF)
|
|
gptkbp:bfsParent
|
gptkb:RAS
|
|
gptkbp:bfsLayer
|
4
|