SOS (guanine nucleotide exchange factor)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein guanine nucleotide exchange factor
gptkbp:activatedBy	gptkb:GRB2 gptkb:receptor_tyrosine_kinases
gptkbp:alias	gptkb:SOS2 gptkb:SOS1 Son of sevenless
gptkbp:determines	X-ray crystallography
gptkbp:discoveredBy	D. Bar-Sagi J. Kuriyan
gptkbp:domain	gptkb:Dbl_homology_domain gptkb:pleckstrin_homology_domain proline-rich region Ras exchanger motif
gptkbp:foundIn	gptkb:Mus_musculus gptkb:Homo_sapiens
gptkbp:function	activates Ras proteins catalyzes GDP-GTP exchange
gptkbp:gene	gptkb:SOS2 gptkb:SOS1
https://www.w3.org/2000/01/rdf-schema#label	SOS (guanine nucleotide exchange factor)
gptkbp:involvedIn	gptkb:MAPK/ERK_signaling_pathway cell differentiation cell proliferation signal transduction
gptkbp:locatedOnChromosome	14q21 (SOS2) 2p22-p16 (SOS1)
gptkbp:memberOf	RasGEF family
gptkbp:mutationAssociatedWith	gptkb:hereditary_gingival_fibromatosis gptkb:Noonan_syndrome
gptkbp:orthologIn	Sos1 (Drosophila melanogaster)
gptkbp:PDB	1XD4 1NVU
gptkbp:regulates	MAPK cascade Ras GTPase activity
gptkbp:reviewedBy	gptkb:Nature gptkb:science Cell
gptkbp:subcellularLocation	gptkb:cytoplasm gptkb:plasma_membrane
gptkbp:UniProtID	Q07889 Q07890
gptkbp:bfsParent	gptkb:RAS_proteins gptkb:RAS_signaling_pathway
gptkbp:bfsLayer	6