|
gptkbp:instanceOf
|
signaling molecule
|
|
gptkbp:aberrantActivationLeadsTo
|
drug resistance
tumorigenesis
|
|
gptkbp:activatedBy
|
gptkb:receptor_tyrosine_kinases
growth factors
|
|
gptkbp:alsoKnownAs
|
gptkb:RAS-RAF-MEK-ERK_pathway
|
|
gptkbp:component
|
gptkb:RAS
gptkb:RAF
MAPK (Mitogen-Activated Protein Kinase)
MAPKK (MAPK kinase)
MAPKKK (MAPK kinase kinase)
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:cancer
developmental disorders
|
|
gptkbp:fourthComponent
|
gptkb:ERK
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RAS-MAPK pathway
|
|
gptkbp:inhibitedBy
|
gptkb:trametinib
gptkb:sorafenib
gptkb:vemurafenib
|
|
gptkbp:involves
|
gptkb:RAF_kinase
gptkb:ERK
gptkb:MEK
gptkb:RAS_protein
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:modulatedBy
|
gene expression
|
|
gptkbp:mutationAssociatedWith
|
gptkb:HRAS_gene
gptkb:NRAS_gene
gptkb:BRAF_gene
gptkb:KRAS_gene
|
|
gptkbp:phosphorylates
|
transcription factors
cytoskeletal proteins
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell proliferation
cell survival
|
|
gptkbp:relatedTo
|
gptkb:PI3K-AKT_pathway
gptkb:Wnt_signaling_pathway
gptkb:JAK-STAT_pathway
|
|
gptkbp:requires
|
embryonic development
tissue homeostasis
|
|
gptkbp:studiedIn
|
cell biology
developmental biology
oncology
|
|
gptkbp:target
|
gptkb:MEK_inhibitors
gptkb:RAF_inhibitors
|
|
gptkbp:thirdComponent
|
gptkb:MEK
|
|
gptkbp:bfsParent
|
gptkb:LZTR1_gene
|
|
gptkbp:bfsLayer
|
7
|