platelet-derived growth factor

URI: https://gptkb.org/entity/platelet-derived_growth_factor
GPTKB entity
Statements (52)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation gptkb:PDGF
gptkbp:actsOn glial cells
fibroblasts
mesenchymal cells
smooth muscle cells
gptkbp:category growth factor
cytokine
gptkbp:discoveredBy gptkb:Russell_Ross
gptkbp:foundIn platelets
gptkbp:function regulates cell growth
stimulates angiogenesis
regulates cell division
gptkbp:gene gptkb:PDGFC
gptkb:PDGFD
gptkb:PDGFA
gptkb:PDGFB
https://www.w3.org/2000/01/rdf-schema#label platelet-derived growth factor
gptkbp:inhibitedBy gptkb:sorafenib
gptkb:imatinib
gptkb:pazopanib
gptkb:sunitinib
gptkbp:locatedOnChromosome chromosome 11 (PDGFD)
chromosome 22 (PDGFB)
chromosome 4 (PDGFC)
chromosome 7 (PDGFA)
gptkbp:medicalUse treatment of diabetic foot ulcers
treatment of chronic wounds
gptkbp:OMIM 190040
gptkbp:overexpressedIn atherosclerosis
pulmonary fibrosis
tumor growth
gptkbp:pathway gptkb:MAPK_pathway
gptkb:PI3K/AKT_pathway
gptkb:JAK/STAT_pathway
gptkbp:recipient gptkb:PDGFR-beta
gptkb:PDGFR-alpha
gptkbp:relatedTo gptkb:cancer
wound healing
fibrosis
gptkbp:structure dimer
gptkbp:subunit A chain
B chain
C chain
D chain
gptkbp:UniProtID P01127
P04085
Q9GZP0
Q9NRA1
gptkbp:bfsParent gptkb:platelet-derived_growth_factor_receptor_beta
gptkb:Platelet-derived_growth_factor_receptor
gptkbp:bfsLayer 7