|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:HCP
gptkb:SHP-1
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:chromosomeArm
|
gptkb:12p13
|
|
gptkbp:discoveredBy
|
Tonks et al.
|
|
gptkbp:discoveredIn
|
1988
|
|
gptkbp:domain
|
gptkb:protein_tyrosine_phosphatase_domain
SH2 domain
|
|
gptkbp:encodes
|
gptkb:Tyrosine-protein_phosphatase_non-receptor_type_6
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000111679
5777
|
|
gptkbp:expressedIn
|
hematopoietic cells
|
|
gptkbp:function
|
protein tyrosine phosphatase activity
negative regulation of cell signaling
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
9642
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PTPN6
|
|
gptkbp:interactsWith
|
gptkb:CD22
gptkb:JAK1
gptkb:Lyn
gptkb:STAT3
gptkb:FcγRIIB
gptkb:SIRPα
|
|
gptkbp:involvedIn
|
immune response regulation
hematopoietic cell signal transduction
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12
|
|
gptkbp:molecularWeight
|
68 kDa
|
|
gptkbp:mutationAssociatedWith
|
leukemia
autoimmune diseases
|
|
gptkbp:OMIM
|
176883
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Ptpn6
|
|
gptkbp:regulates
|
gptkb:T_cell_receptor_signaling_pathway
gptkb:B_cell_receptor_signaling_pathway
gptkb:JAK/STAT_signaling_pathway
apoptosis
cell proliferation
inflammatory response
differentiation of hematopoietic cells
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:P29350
|
|
gptkbp:bfsParent
|
gptkb:protein_tyrosine_phosphatases
|
|
gptkbp:bfsLayer
|
6
|