|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
CD172a
SHPS-1
|
|
gptkbp:associatedWith
|
immunotherapy
macrophage checkpoint
|
|
gptkbp:domain
|
immunoreceptor tyrosine-based inhibitory motifs (ITIMs)
|
|
gptkbp:encodedBy
|
SIRPA gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000198053
|
|
gptkbp:expressedIn
|
neurons
myeloid cells
|
|
gptkbp:fullName
|
gptkb:Signal-regulatory_protein_alpha
|
|
gptkbp:function
|
cell surface receptor
negative regulator of receptor tyrosine kinase-coupled signaling processes
|
|
gptkbp:gene
|
gptkb:SIRPA
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:9666
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SIRPα
|
|
gptkbp:interactsWith
|
gptkb:CD47
|
|
gptkbp:locatedOnChromosome
|
gptkb:20p13
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:molecularWeight
|
~90 kDa
|
|
gptkbp:OMIM
|
601734
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
Sirpa (mouse)
|
|
gptkbp:PDB
|
2JJS
|
|
gptkbp:role
|
immune response regulation
inhibition of phagocytosis
|
|
gptkbp:species
|
gptkb:human
gptkb:mouse
|
|
gptkbp:structure
|
gptkb:immunoglobulin_superfamily
|
|
gptkbp:UniProtID
|
gptkb:P78324
|
|
gptkbp:bfsParent
|
gptkb:PTPN6
|
|
gptkbp:bfsLayer
|
7
|