Tyrosine-protein phosphatase non-receptor type 6
GPTKB entity
Statements (30)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
gptkb:PTPN6
gptkb:SHP-1 |
| gptkbp:associatedWith |
leukemia
autoimmune diseases |
| gptkbp:biologicalProcess |
phosphatase activity
|
| gptkbp:cellularComponent |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:domain |
gptkb:protein_tyrosine_phosphatase_domain
SH2 domain |
| gptkbp:encodedBy |
PTPN6 gene
|
| gptkbp:expressedIn |
hematopoietic cells
|
| gptkbp:function |
protein tyrosine phosphatase activity
negative regulation of cell signaling |
| https://www.w3.org/2000/01/rdf-schema#label |
Tyrosine-protein phosphatase non-receptor type 6
|
| gptkbp:inhibitedBy |
B cell receptor signaling
T cell receptor signaling |
| gptkbp:length |
595 amino acids
|
| gptkbp:locatedOnChromosome |
gptkb:12p13
|
| gptkbp:molecularWeight |
68 kDa
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologIn |
gptkb:Mus_musculus
gptkb:Rattus_norvegicus |
| gptkbp:PDB |
2SHP
3PS5 |
| gptkbp:regulates |
gptkb:JAK/STAT_signaling_pathway
immune response |
| gptkbp:UniProtID |
gptkb:P29350
|
| gptkbp:bfsParent |
gptkb:PTPN6
|
| gptkbp:bfsLayer |
7
|