Tyrosine-protein phosphatase non-receptor type 6

URI: https://gptkb.org/entity/Tyrosine-protein_phosphatase_non-receptor_type_6
GPTKB entity
Statements (30)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alsoKnownAs gptkb:PTPN6
gptkb:SHP-1
gptkbp:associatedWith gptkb:leukemia
autoimmune diseases
gptkbp:biologicalProcess phosphatase activity
gptkbp:cellularComponent gptkb:nucleus
gptkb:cytoplasm
gptkbp:domain gptkb:protein_tyrosine_phosphatase_domain
SH2 domain
gptkbp:encodedBy PTPN6 gene
gptkbp:expressedIn hematopoietic cells
gptkbp:function protein tyrosine phosphatase activity
negative regulation of cell signaling
gptkbp:inhibitedBy B cell receptor signaling
T cell receptor signaling
gptkbp:length 595 amino acids
gptkbp:locatedOnChromosome gptkb:12p13
gptkbp:molecularWeight 68 kDa
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Rattus_norvegicus
gptkbp:PDB 2SHP
3PS5
gptkbp:regulates gptkb:immune_response
gptkb:JAK/STAT_signaling_pathway
gptkbp:UniProtID gptkb:P29350
gptkbp:bfsParent gptkb:PTPN6
gptkbp:bfsLayer 7
https://www.w3.org/2000/01/rdf-schema#label Tyrosine-protein phosphatase non-receptor type 6