Tyrosine-protein phosphatase non-receptor type 6

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alsoKnownAs	gptkb:PTPN6 gptkb:SHP-1
gptkbp:associatedWith	gptkb:leukemia autoimmune diseases
gptkbp:biologicalProcess	phosphatase activity
gptkbp:cellularComponent	gptkb:nucleus gptkb:cytoplasm
gptkbp:domain	gptkb:protein_tyrosine_phosphatase_domain SH2 domain
gptkbp:encodedBy	PTPN6 gene
gptkbp:expressedIn	hematopoietic cells
gptkbp:function	protein tyrosine phosphatase activity negative regulation of cell signaling
gptkbp:inhibitedBy	B cell receptor signaling T cell receptor signaling
gptkbp:length	595 amino acids
gptkbp:locatedOnChromosome	gptkb:12p13
gptkbp:molecularWeight	68 kDa
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:orthologIn	gptkb:Mus_musculus gptkb:Rattus_norvegicus
gptkbp:PDB	2SHP 3PS5
gptkbp:regulates	gptkb:immune_response gptkb:JAK/STAT_signaling_pathway
gptkbp:UniProtID	gptkb:P29350
gptkbp:bfsParent	gptkb:PTPN6
gptkbp:bfsLayer	7
http://www.w3.org/2000/01/rdf-schema#label	Tyrosine-protein phosphatase non-receptor type 6