T cell receptor signaling pathway
GPTKB entity
Statements (35)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
biological pathway
|
| gptkbp:activatedBy |
T cell activation
|
| gptkbp:cause |
cell differentiation
cell proliferation cytokine production |
| gptkbp:describedBy |
KEGG: hsa04660
Reactome: R-HSA-202403 |
| https://www.w3.org/2000/01/rdf-schema#label |
T cell receptor signaling pathway
|
| gptkbp:involves |
gptkb:MAPK_pathway
gptkb:NFAT gptkb:NF-kB gptkb:ZAP-70 gptkb:LAT gptkb:Ras gptkb:CD3_complex gptkb:Lck gptkb:AP-1 gptkb:PLC-gamma1 gptkb:SLP-76 cell surface receptor |
| gptkbp:occurredIn |
T lymphocytes
|
| gptkbp:partOf |
adaptive immune response
|
| gptkbp:regulates |
inhibitory receptors
co-stimulatory signals |
| gptkbp:target |
immunosuppressive drugs
biologic therapies |
| gptkbp:bfsParent |
gptkb:RasGRP
gptkb:CD3E_gene gptkb:PTPN2 gptkb:PTPN6 gptkb:LAT_(gene) gptkb:LAT_(protein) gptkb:PIK3CD_(human) gptkb:CTLA4_gene |
| gptkbp:bfsLayer |
7
|