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gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:p110_alpha
gptkb:phosphatidylinositol_4,5-bisphosphate_3-kinase_catalytic_subunit_alpha_isoform
gptkb:PIK3CA
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:endometrial_cancer
colorectal cancer
|
|
gptkbp:discoveredBy
|
gptkb:Jean_Zhao
gptkb:Lewis_Cantley
|
|
gptkbp:encodes
|
gptkb:p110α_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000121879
5290
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:fullName
|
gptkb:phosphatidylinositol-4,5-bisphosphate_3-kinase_catalytic_subunit_alpha
|
|
gptkbp:function
|
catalytic subunit of PI3K
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
8975
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PI3KCA
|
|
gptkbp:involvedIn
|
gptkb:PI3K/AKT_signaling_pathway
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_3
3q26.32
|
|
gptkbp:mutationAssociatedWith
|
oncogenic
E542K
E545K
H1047R
tumorigenesis
increased cell proliferation
constitutive activation of PI3K
|
|
gptkbp:OMIM
|
171834
|
|
gptkbp:orthologInMouse
|
gptkb:Pik3ca
|
|
gptkbp:pathway
|
gptkb:mTOR_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
insulin signaling pathway
|
|
gptkbp:product
|
gptkb:phosphatidylinositol_4,5-bisphosphate_3-kinase_catalytic_subunit_alpha_isoform
|
|
gptkbp:regulates
|
cell proliferation
cell survival
metabolism
angiogenesis
cell growth
|
|
gptkbp:significance
|
biomarker for targeted therapy
predictive of response to PI3K inhibitors
prognostic marker in cancer
|
|
gptkbp:target
|
gptkb:alpelisib
PI3K inhibitors
|
|
gptkbp:UniProtID
|
gptkb:P42336
|
|
gptkbp:bfsParent
|
gptkb:PIK3CA
|
|
gptkbp:bfsLayer
|
5
|