phosphoinositide 3-kinase family
GPTKB entity
Statements (30)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:associatedWith |
gptkb:cancer
gptkb:diabetes inflammatory diseases |
| gptkbp:catalyzes |
conversion of PIP2 to PIP3
|
| gptkbp:contains |
gptkb:Class_IV_PI3K
gptkb:Class_III_PI3K gptkb:Class_II_PI3K gptkb:Class_I_PI3K |
| gptkbp:discoveredBy |
gptkb:Lewis_Cantley
|
| gptkbp:EC_number |
2.7.1.153
|
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:function |
phosphorylation of phosphoinositides
|
| https://www.w3.org/2000/01/rdf-schema#label |
phosphoinositide 3-kinase family
|
| gptkbp:involvedIn |
cell differentiation
cell proliferation cell survival cell growth intracellular signaling |
| gptkbp:proteinFamily |
gptkb:PIK3_genes
|
| gptkbp:regulates |
gptkb:AKT_signaling_pathway
gptkb:mTOR_pathway cell metabolism |
| gptkbp:subunit |
catalytic subunit
regulatory subunit |
| gptkbp:target |
PI3K inhibitors
|
| gptkbp:bfsParent |
gptkb:PIK3CA
gptkb:PIK3CG gptkb:class_III_PI3K |
| gptkbp:bfsLayer |
5
|