phosphoinositide 3-kinase complex

URI: https://gptkb.org/entity/phosphoinositide_3-kinase_complex
GPTKB entity
Statements (44)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:activeIn gptkb:cytoplasm
gptkb:plasma_membrane
gptkbp:alternativeName gptkb:PI3K_complex
gptkb:phosphatidylinositol_3-kinase_complex
gptkbp:associatedWith gptkb:cancer
gptkb:diabetes
leukemia
inflammatory diseases
gptkbp:catalyzes conversion of PIP2 to PIP3
gptkbp:discoveredBy gptkb:Lewis_Cantley
gptkbp:encodedBy gptkb:PIK3CA_gene
gptkb:PIK3CB_gene
gptkb:PIK3CD_gene
gptkb:PIK3CG_gene
gptkbp:foundIn eukaryotic cells
gptkbp:function phosphorylation of phosphoinositides
gptkbp:hasComponent catalytic subunit
regulatory subunit
gptkbp:hasType gptkb:Class_III_PI3K
gptkb:Class_II_PI3K
gptkb:Class_I_PI3K
https://www.w3.org/2000/01/rdf-schema#label phosphoinositide 3-kinase complex
gptkbp:involvedIn gptkb:PI3K/AKT_signaling_pathway
cell survival
metabolism
cancer progression
cell growth regulation
gptkbp:modulatedBy gptkb:insulin
cytokines
growth factors
oncogenes
gptkbp:regulates apoptosis
cell proliferation
angiogenesis
glucose metabolism
gptkbp:subunit gptkb:p101
gptkb:p110
p50
p55
p85
gptkbp:target PI3K inhibitors
gptkbp:bfsParent gptkb:PIK3CB
gptkbp:bfsLayer 5