|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:CDC42
gptkb:RAC1
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:neurofibromatosis_type_2
|
|
gptkbp:encodedBy
|
gptkb:PAK1_gene
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.1
|
|
gptkbp:fullName
|
gptkb:p21-activated_kinase_1
|
|
gptkbp:function
|
cell proliferation
cell survival
signal transduction
cell motility
regulation of cytoskeleton
serine/threonine kinase activity
|
|
gptkbp:gene
|
gptkb:PAK1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PAK1
|
|
gptkbp:interactsWith
|
gptkb:PIX
gptkb:GIT1
gptkb:NCK1
gptkb:PAK2
gptkb:PAK3
|
|
gptkbp:involvedIn
|
gptkb:MAPK_signaling_pathway
apoptosis
cell cycle regulation
cancer progression
|
|
gptkbp:length
|
545
|
|
gptkbp:locatedOnChromosome
|
11q13.5-q14
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
68 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
gptkb:1YHV
gptkb:2F57
|
|
gptkbp:phosphorylates
|
gptkb:MEK1
gptkb:BAD
gptkb:RAF1
gptkb:LIMK1
gptkb:MERLIN
|
|
gptkbp:postTranslationalModification
|
phosphorylation
autophosphorylation
|
|
gptkbp:regulates
|
autoinhibition
activation by GTPases
|
|
gptkbp:structure
|
contains kinase domain
contains p21-binding domain
|
|
gptkbp:UniProtID
|
Q13153
|
|
gptkbp:bfsParent
|
gptkb:Ser338_(CRAF)
|
|
gptkbp:bfsLayer
|
6
|